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pentobarbital will decrease the level or result of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers lessens plasma concentration of abemaciclib and its metabolites.Pentobarbital belongs to a class of medicines known as barbiturates which